This study was undertaken to define the usefulness of preoperative CA-125 assay as a diagnostic tumor marker in differentiating malignancy from benign ovarian mass. Serum CA-125 were measured by Microparticle Enzyme Immunoassay(MEIA) in 94
patients
with
ovarian mass.
@ES The results were follows
@EN 1. The mean value of preoperative serum CA-125 was 18.40u/ml in benign mass and 225.99u/ml in malignant ovarian mass(P<0.001).
2. The positive rate of CA-125 in benign ovarian mass was 10%, compared 80% in malignant ovarian mass.
3. In analysis of histologic type, positive rate of serum CA-125 in malignant serous tumor was 82%, compared 50% in malignant mucinous tumor.
4. No statistically significant correlation was observed CA-125 value and patient's age.
5. The sensitivity, positive predictive value & negative predictive value were 80%, 90%, 60% & 96%, respectively in cut off value 35u/ml. And increasing cut off value 65u/ml, sensitivity, specificity, positive predictive value & negative
predictive
value were 40%, 96%, 67%, 90%, respectively.
These data suggest the preoperative serum CA-125 level correlate with maignant status in ovarian mass. And cut off value 35u/ml was better than 65u/ml in screening for ovarian cancer.
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